diff --git a/CMakeLists.txt b/CMakeLists.txt
index d8adf6c396f..9d369d2d453 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -1296,6 +1296,15 @@ if(WITH_PYTHON_MODULE)
     message(STATUS "GTests not compatible with Python module, disabling WITH_GTESTS")
     set(WITH_GTESTS OFF)
   endif()
+  if(APPLE)
+    if(WITH_COMPILER_ASAN)
+      message(STATUS
+        "ASAN is not compatible with Python module on APPLE, "
+        "disabling WITH_COMPILER_ASAN"
+      )
+      set(WITH_COMPILER_ASAN OFF)
+    endif()
+  endif()
 endif()